1. In a large bowl combine ground beef, breadcrumbs, egg, onion powder, garlic powder, Worcestershire sauce, salt and pepper and mix.
2. Divide the mixture into quarters and shape into patties.
3. Heat the grill to medium heat.
4. Grill burgers for 6-8 minutes on each side.
5. Add cheese and toast buns.
6. Serve with an assortment of toppings and condiments.